PCCA Base Technologies

Atrevis Hydrogel is an advanced topical base that uses a unique hydrogel polymer network along with natural enhancers to drive testosterone far beyond the reach of other bases.

Ideal In Formulations For:

• Male Hormone/Andropause

Benefits:

• Alcohol free
• Quick absorption, smooth texture, no greasy residue
• Superior testosterone delivery

Dosage Form:

• Topical gel

Common Drug Type:

• Hormones

Biopeptide Biocosmetic is a pharmacy compounding cream designed for cosmetic facial use. This advanced, phosphate-based emulsion system is packed with high concentrations of the two biopeptides palmitoyl tripeptide-5 and palmitoyl pentapeptide-4.

Ideal in formulations for:

• Dermatology
• Cosmeceuticals

Common APIs:

• Sodium Hyaluronate
• Niacinamide
• Retinol Molecular
• Estriol
• Progesterone

Clarifying is and elegant compounding topical emulsion created for patients with problem skin

Ideal in formulations for:

• Dermatology
• Cosmeceuticals
• Acne/problem skin
• Rosacea

Common APIs:

• Azelaic Acid
• Benzoyl Peroxide
• Clindamycin
• Ivermectin
• Metronidazole
• Tretinoin

EctoSeal P2G, our revolutionary powder-to hydrogel topical base, is the first natural, biodegradable polymer base created for wound care preparations.  Developed using extremolytes and a prebiotic, EctoSeal P2G supports an optimal skin microbiome for better overall formulations

Ideal in formulations for:

• Internal medicine/family practice
• Wound care specialists
• Surgery
• Hospice
• Dermatology
• Veterinary Medicine

Common APIs:

• Doxycycline
• Lidocaine
• Metronidazole
• Misoprostol
• Mupirocin
• Naltrexone HCl
• Phenytoin
• Tobramycin
• Triamcinolone

Ellage® Anhydrous Vaginal is the first anhydrous base developed specifically for vaginal applications. It is designed to be gentle on vaginal tissue, release drugs and maintain contact with the mucosa, all while providing a uniquely pleasant experience for patients.

Ideal In Formulations For:

• Hormone Replacement Therapy (HRT)

Benefits:

• No irritation incredibly gentle on mucosal tissue
• In vitro testing shows that Ellage has significant potential to minimize leakage of medication

Dosage Form:

• Vaginal

Common Drug Type:

• Hormones
• Antimicrobials
• Antifungals
• Anti-inflammatories
• Anaesthetics
• Vasodilators

Lipoderm is the ideal base for deep-penetrating topical formulations for local and systemic absorption of active pharmaceutical ingredients (APIs). It is scientifically proven to deliver APIs through the skin and is supported by an ever-growing portfolio of peer-reviewed journal publications.

Ideal In Formulations For:

• Acute or chronic pain
• Anxiety
• Nausea
• Veterinary medicine

Benefits:

• Up to 4 drugs can be combined in one formulation
• Developed to enhance penetration of drugs through the epidermis and dermis
• Quick absorption, smooth texture, non-sticky

Dosage Form:

• Permeation enhancing base

Common Drug Type:

• Analgesics and anaesthetics
• Anxiolytics
• Antiemetics

Lipoderm ActiveMax pairs the patented Lipoderm core technology with the capability to hold active ingredients in salt form at high concentrations, achieving enhanced skin permeation with higher drug capacity.

Ideal In Formulations For:

• Acute or chronic pain
• Anxiety
• Nausea
• Veterinary medicine

Benefits:

• Developed to hold drugs in high concentrations
• Up to 4 drugs can be combined in one formulation

Dosage Form:

• Transdermal cream

Common Drug Type:

• Analgesics and anaesthetics
• Anxiolytics
• Antiemetics

LoxaSperse can be a real game changer for patients suffering from chronic, recurrent or resistant sinus conditions. This innovative powder base for nasal nebulisations and irrigations was created to go right to the desired site of action.

Ideal in formulations for:

• ENT (sinusitis)
• Wound care

Common APIs:

• Budesonide
• Gentamicin
• Tobramycin

LoxOral® is an all-in-one excipient base that can be used in oral capsule formulations with many types of drugs. LoxOral is much more than a filler – it’s an innovative capsule excipient base that delivers powerful benefits for patients.

Ideal In Formulations For:

• Hormone Replacement Therapy
• Veterinary

Benefits:

• Even distribution: Well-defined, uniform particle size creates improved distribution
• Improved dissolution: Enhances the release of many types of drugs – including poorly soluble drugs – potentially leading to improved absorption.
• Optimal stability
• Reduce static and clumping, improves flowability.

Dosage Form:

• Oral

Common Drug Type:

• Can be used with an extensive range of drug types

MBK (Fatty Acid) base is stable and has a low irritation profile it exhibits excellent mould release characteristics and does not require mould lubrication. It has a low melting point (body temperature). Base MBK has emulsifying properties and may be used as a water-absorbing suppository base as well.

Ideal in formulations for:

• Rectal/vaginal conditions

Common APIs

• Diazepam
• Hydrocortisone
• Ketamine HCl
• Lidocaine
• Nifedipine

Mucolox is a revolutionary base that combines the benefits of water-solubility with unprecedented staying power. It can be used with active pharmaceutical ingredients to help deliver long-lasting adhesion for oral and other mucosal surfaces,including oral, rectal, vaginal and oesophageal/gut preparations as well as wound care.

Ideal In Formulations For:

• Vaginal HRT
• Oral mucositis
• Proctitis

Benefits:

• Polymer network with excellent muco-adhesive properties increasing the contact time of drugs to the mucosal surface
• Does not wash out with water or secretions
• Neutral taste
• Can be diluted with water

Dosage Form:

• Oral, vaginal or rectal gel
• Oral mouthwash or spray
• Oesophageal/gut suspension

Common Drug Type:

• Hormones
• Anaesthetics
• Corticosteroids

NataTroche tastes great, has a pleasant texture, melts quickly, is made with natural ingredients and its lipid composition improves contact time with oral mucosa. It is excellent at masking bitter ingredients such as progesterone, which help improve patient compliance.

Ideal In Formulations For:

• Sub-lingual HRT

Benefits:

• Fast dissolving lozenge base
• Improves contact time with oral mucosa, potentially improving absorption
• Smooth, creamy base with a pleasant taste
• Masks bitter flavours

Dosage Form:

• Lozenge/Troche

Common Drug Type:

• Hormones

PermE8 is the permeation-enhancing topical base, using next-generation technology in a silky, smooth anhydrous system to achieve exceptional drug delivery through the skin.

Ideal In Formulations For:

• Paediatrics
• Palliative care
• Hospice and oncology
• Veterinary medicine

Benefits:

• Up to 4 drugs can be combined in one formulation
• Anhydrous
• Silky, smooth texture providing better application

Dosage Form:

• Permeation – enhancing gel

Common Drug Type:

• Analgesics and anaesthetics

A polyethylene and mineral oil gel base commonly used for topical and oral preparations. It has a soft elegant feel and is completely anhydrous. Plasticized Base is great for water sensitive actives. It is used for topical applications.

Ideal in formulations for:

• Dental
• Topical anaesthetics

Common APIs

• Acyclovir
• Benzocaine
• Lidocaine
• Tetracaine

PCCA’s Poloxamer Gels are able to perform as a carrier of water-soluble drugs for percutaneous absorption. When chilled, the gel has a liquid consistency, is odourless, colourless and non-greasy. It is an emulsifier with soap-like characteristics.

Ideal In Formulations For:

• Veterinary medicine
• Wounds and burns
• Ear and sinus cavities

Benefits:

• A bio-adhesive, thermoreversible gel
• At cold temperatures it is liquid, at body temperature it becomes a gel

Polyglycol Troche base has sweetness and suspending agents. Simply “chip out” the required amount, melt it, add your active ingredient and flavour, stir and pour into a troche mould or tablet triturate mould.

Ideal in formulations for:

• HRT
• Men’s health
• Women’s health
• Paediatrics
• Dental/ENT (thrush/mucositis)

Common APIs

• Sildenafil
• Pilocarpine
• Progesterone
• Testosterone

PracaSil-Plus features a proprietary blend of ingredients, including silicones (in a semipermeable polymer network) and pracaxi oil (which is rich in skin-friendly fatty acids and lipids), it has been helping make a huge difference for patients who want to improve the appearance of scars, including keloid and acne scars.

Ideal In Formulations For:

• All scars, including new, old, keloid, hypertrophic and surgical
• Burns and diabetic wounds
• Stretch marks

Benefits:

• Anhydrous topical silicone base created to improve the appearance of scars
• Can be used alone or combined with various drugs to treat scar tissue
• Contains pracaxi oil rich in skin-friendly fatty acids and lipids

Dosage Form:

• Topical gel

Common Drug Type:

• Cotricosteroids and antioxidants
• Anaesthetics and NSAID’s
• Antibiotics and antifungals

Rapid Dissolve Tablets (RDTs) are an innovative, versatile dosage form that quickly melts in the mouth, allowing the API to be released surrounded by a sweet, flavoured powder.  They offer patients a customisable, portable and easy-to-use options for medications.  They can be taken orally without the need for water, or held in the mouth for buccal/sublingual absorption, and they dissolve quickly.  Therefore, RDTs can be the perfect solution for patients with otherwise limited dosing options.

Ideal in formulations for:

• HRT
• Men’s health
• Women’s health

Common APIs:

• Hydrocortisone
• Ketamine HCl
• Naltrexone HCl
• Progesterone
• Tadalafil
• Testosterone

Designed to efficiently deliver a wide range of drugs with varying molecular weights — including high molecularweight (HMW) substances — SubMagna SL HMW is a state of-the-art, anhydrous, self-emulsifying and permeation-enhancing sublingual suspension vehicle

Ideal in formulations for:

• Weight Loss
• HRT
• Sexual Dysfunction

Common APIs:

• Semaglutide
• Naltrexone
• Ketamine
• Progesterone
• Testosterone
• Sildenafil

SuspendIt is our all-in-one suspending base that has a patented polymer complex. The unique thixotropic flow means it thins as it’s shaken and thickens upon standing, allowing for rapid redispersion of active pharmaceutical ingredients (APIs) and minimising sedimentation.

Ideal In Formulations For:

• Paediatric
• Hospice and oncology
• Veterinary medicine

Benefits:

• Thins when shaken and thickens when standing allowing for rapid redispersion of drugs
• Sugar free with unique natural sweetener
• Pleasant neutral taste
• Ideal for formulations without sugar, casein or gluten

Dosage Form:

• Oral suspension

Common Drug Type:

• Proton pump inhibitors
• Corticosteroids
• Anticonvulsants

SuspendIt Anhydrous is ideal for pharmaceutical ingredients (APIs) that are unstable in water or have incompatibilities in some aqueous vehicles, SuspendIt Anhydrous is unlike any other oral suspension vehicle

Ideal in formulations for:

• Paediatrics
• Geriatrics
• Hospice
• APIs unstable in water
• Veterinary medicine
• Formulas needing extended maximum BUDs

Common APIs:

• Atomoxetine
• Ciprofloxacin
• Doxycycline
• Enrofloxacin
• Metronidazole
• Valacyclovir

VersaBase Cream is an elegant, durable topical cream, an ideal base for topical and vaginal hormone replacement therapy (HRT). It simulates the natural moisturising barrier of the skin through its emulsion system and rubs in quickly, leaving a soft and silky feel.

Ideal In Formulations For:

• Hormone replacement
• Antifungals
• Corticosteroids

Benefits:

• Non-ionic emulsion system that stimulates the natural moisturising barrier of the skin
• Hypoallergenic, odour free and oil free

Dosage Form:

• Topical cream
• Vaginal cream

Common Drug Type:

• Hormones

VersaBase Gel is transparent and smooth, with a silky feel that spreads and absorbs easily. It is extremely stable and can be used topically, vaginally and rectally. This base can be used in combination with MucoLox™ for patients with vaginal and rectal conditions that would benefit from enhanced mucosal adherence.

Ideal In Formulations For:

• Female / Male Hormone replacement

Benefits:

• Alcohol free
• Quick absorption, smooth texture, no greasy residue

Dosage Form:

• Topical, Vaginal or Rectal gel

Common Drug Type:

• Hormones

VersaBase Anhydrous HRT is the pharmacy compounding industry’s first proprietary anhydrous topical base developed specifically to deliver female hormones through the skin.  It is also the latest addition to the VersaBase family of compounding bases.

Ideal in formulations for:

• HRT

Common APIs

• DHEA
• Estradiol
• Estriol
• Progesterone
• Testosterone

WO6® Anhydrous Topical Gel is an elegant, stable base that is suitable for a broad range of dermatological and cosmetic applications. W06 is an anhydrous base, it allows it to accommodate ingredients that are unstable in aqueous environments. It is also not tacky or oily, leaving a light, silky feel on the skin that patients will appreciate.

Ideal In Formulations For:

• Dermatology
• Cosmeceuticals
• Veterinary medicine

Benefits:

• Anhydrous topical base for a broad range of applications
• Easy application – no greasy or tacky residue
• Emollient properties which moisturise and softens the skin in use
• Formulated without out preservatives, soya, petrolatum / mineral oil, gluten

Dosage Form:

• Topical gel

XemaTop is a base designed for the use in compounding formulations for patients with eczema, psoriasis and xerosis

Ideal in formulations for:

• Dermatology
• Cosmeceuticals
• Eczema
• Psoriasis
• Xerosis (dry skin)

Common APIs:

• Clobetasol Propionate
• Ivermectin
• Ketotifen
• Naltrexone HCl
• Tretinoin

XyliFos is an excipient base developed to be used in combination with LoxaSperse to maximise the solubilising/dispersing properties.

Ideal in formulations for:

• Used along with LoxaSperse

Common APIs:

• Budesonide
• Gentamicin
• Tobramycin

ZoSil® is the industry’s first topical gel base developed specifically for use in veterinary. This exclusive silicone hydrogel base is designed to topically deliver drugs into animal skin. Specifically, it is ideal as a base in formulations for dermatitis and wound care.

Ideal In Formulations For:

• Veterinary medicine

Benefits:

• Silicone hydrogel developed specifically for animal skin
• Can be used on mammals, birds and reptiles
• Includes conditioners to promote healthy, shiny fur without matting or gumming

Dosage Form:

• Topical gel

Common Drug Type:

• Antibiotics
• Antifungals
• Anti-inflammatories
• Anaesthetics
• Antiseptics